Hotel has 27 rooms, 10 are 5 star deluxe suites with the personalized service, all rooms are air conditioning and with Internet access.
Rooms at the Santa Isabel have been tastefully appointed and decorated to offer an authentic colonial feel, accommodations have original tile flooring, French doors opening onto a spacious terrace, wrought-iron beds and faux period furnishings. Ten west-facing rooms share the hotel's long terrace, divided into generous sections by planters, which overlooks the Plaza de Armas and makes for a supremely relaxing spot from where to gaze at the lovely environs in the company of a cocktail or book. Four rooms face neighboring buildings on the east end of Obispo and should probably be avoided by anyone interested in a view, which is afforded by one room with a window facing the Havana bay and the port area.
The hotel's nine junior suites have the same interior design as the standards but offer extra space a spacious seating area. All face Plaza de Armas and come equipped with Internet.
A popular room with visiting VIPs, actor Jack Nicholson, performer artist known as Sting and US president Jimmy Carter have stayed here, the hotel suite adds space to the already splendid junior suites.